Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice

AMP-activated protein kinase (AMPK) is a multifunctional kinase that negatively regulates the mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) signaling, two signaling pathways linked to pain promotion after injury, such as surgical incision. AMPK can be activated d...

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Dettagli Bibliografici
Pubblicato in:J Pharmacol Exp Ther
Autori principali: Inyang, Kufreobong E., Burton, Michael D., Szabo-Pardi, Thomas, Wentworth, Emma, McDougal, Timothy A., Ramirez, Eric D., Pradhan, Grishma, Dussor, Gregory, Price, Theodore J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2019
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750189/
https://ncbi.nlm.nih.gov/pubmed/31324647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.258400
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