SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease

SARM1 (sterile α and HEAT/armadillo motif–containing protein) is a member of the MyD88 (myeloid differentiation primary response gene 88) family, which mediates innate immune responses. Because inactivation of SARM1 prevents various forms of axonal degeneration, we tested whether it might protect ag...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Zhu, Caihong, Li, Bei, Frontzek, Karl, Liu, Yingjun, Aguzzi, Adriano
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446871/
https://ncbi.nlm.nih.gov/pubmed/30842236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171885
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