Ablation of progranulin augments microglial activation and accelerates prion progression

Abstract Mutations or polymorphisms in GRN, encoding the CNS glycoprotein progranulin (PGRN), have been linked to several neurodegenerative diseases. In this study, we explored the role of PGRN in prion diseases. We observed that prion infection upregulated microglial PGRN expression. Following intr...

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Autors principals: Bei Li, Yiyue Shi, Wenyu Hou, Haoyuan Guan, Jun Li, Tuo Yi, Wei Li, Donglin Cai, Petra Schwarz, Adriano Aguzzi, Caihong Zhu
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-10-01
Col·lecció:Acta Neuropathologica Communications
Matèries:
Progranulin
Prion disease
Microglia
Neuroinflammation
Neurodegeneration
Accés en línia:https://doi.org/10.1186/s40478-025-02128-3
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