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Kinesin-binding protein ensures accurate chromosome segregation by buffering KIF18A and KIF15

Mitotic kinesins must be regulated to ensure a precise balance of spindle forces and accurate segregation of chromosomes into daughter cells. Here, we demonstrate that kinesin-binding protein (KBP) reduces the activity of KIF18A and KIF15 during metaphase. Overexpression of KBP disrupts the movement...

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Bibliografski detalji
Izdano u:J Cell Biol
Glavni autori: Malaby, Heidi L.H., Dumas, Megan E., Ohi, Ryoma, Stumpff, Jason
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446846/
https://ncbi.nlm.nih.gov/pubmed/30709852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201806195
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