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KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle

KIF18A (kinesin-8) is required for mammalian mitotic chromosome alignment. KIF18A confines chromosome movement to the mitotic spindle equator by accumulating at the plus-ends of kinetochore microtubule bundles (K-fibers), where it functions to suppress K-fiber dynamics. It is not understood how the...

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Publicat a:Life Sci Alliance
Autors principals: Malaby, Heidi LH, Lessard, Dominique V, Berger, Christopher L, Stumpff, Jason
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337737/
https://ncbi.nlm.nih.gov/pubmed/30655363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800169
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