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A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A
Metaphase chromosome positioning depends on Kif18A, a kinesin-8 that accumulates at and suppresses the dynamics of K-MT plus ends. By engineering Kif18A mutants that suppress MT dynamics but fail to concentrate at K-MT plus-ends, we identify a mechanism that allows Kif18A to accumulate at K-MT plus...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172727/ https://ncbi.nlm.nih.gov/pubmed/21884977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.07.022 |
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