Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress

Cells respond to stress in the ER by initiating the widely conserved unfolded protein response. Activation of the ER transmembrane nuclease IRE1 leads to the degradation of specific mRNAs, but how this pathway affects the ability of cells to recover from stress is not known. Here, we show that degra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Bae, Donghwi, Moore, Kristin A., Mella, Jessica M., Hayashi, Samantha Y., Hollien, Julie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446841/
https://ncbi.nlm.nih.gov/pubmed/30787040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201809027
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