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IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
Endoplasmic reticulum (ER) is responsible for folding of secreted and membrane proteins in eukaryotic cells. Disruption of ER protein folding leads to ER stress. Chronic ER stress can cause cell death and is proposed to underlie the pathogenesis of many human diseases. Inositol-requiring enzyme 1 (I...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290636/ https://ncbi.nlm.nih.gov/pubmed/22219383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-08-0663 |
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