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IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin

Endoplasmic reticulum (ER) is responsible for folding of secreted and membrane proteins in eukaryotic cells. Disruption of ER protein folding leads to ER stress. Chronic ER stress can cause cell death and is proposed to underlie the pathogenesis of many human diseases. Inositol-requiring enzyme 1 (I...

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書目詳細資料
Main Authors: Chiang, Wei-Chieh, Messah, Carissa, Lin, Jonathan H.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290636/
https://ncbi.nlm.nih.gov/pubmed/22219383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-08-0663
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