Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma

PURPOSE: Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in adults. Here, we examined the importance of hypoxia in UM growth and tested the anti-tumor effects of arylsulfonamide 64B, an inhibitor of the hypoxia-induced factor (HIF) pathway in animal models of UM and inves...

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Pubblicato in:Clin Cancer Res
Autori principali: Dong, Lei, You, Shuo, Zhang, Qing, Osuka, Satoru, Devi, Narra S, Kaluz, Stefan, Holmes, Jalisa Nicole, Yang, Hua, Chen, Guoliang, Wang, Binghe, Grossniklaus, Hans E., Van Meir, Erwin G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445693/
https://ncbi.nlm.nih.gov/pubmed/30563937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1368
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