Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with co-factors p300/CBP

PURPOSE: The hypoxia inducible factor-1 (HIF-1) plays a critical role in tumor adaptation to hypoxia, and its elevated expression correlates with poor prognosis and treatment failure in cancer patients. In this study, we determined whether 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phe...

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מידע ביבליוגרפי
Main Authors: Yin, Shaoman, Kaluz, Stefan, Devi, Narra S., Jabbar, Adnan A., de Noronha, Rita G., Mun, Jiyoung, Zhang, Zhaobin, Boreddy, Purushotham R., Wang, Wei, Wang, Zhibo, Abbruscato, Thomas, Chen, Zhengjia, Olson, Jeffrey J., Zhang, Ruiwen, Goodman, Mark M., Nicolaou, K.C., Van Meir, Erwin G.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518680/
https://ncbi.nlm.nih.gov/pubmed/22923450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0861
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