Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with co-factors p300/CBP

PURPOSE: The hypoxia inducible factor-1 (HIF-1) plays a critical role in tumor adaptation to hypoxia, and its elevated expression correlates with poor prognosis and treatment failure in cancer patients. In this study, we determined whether 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phe...

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Detalhes bibliográficos
Main Authors: Yin, Shaoman, Kaluz, Stefan, Devi, Narra S., Jabbar, Adnan A., de Noronha, Rita G., Mun, Jiyoung, Zhang, Zhaobin, Boreddy, Purushotham R., Wang, Wei, Wang, Zhibo, Abbruscato, Thomas, Chen, Zhengjia, Olson, Jeffrey J., Zhang, Ruiwen, Goodman, Mark M., Nicolaou, K.C., Van Meir, Erwin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518680/
https://ncbi.nlm.nih.gov/pubmed/22923450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0861
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