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Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

Kinetochore localized Mad1 is essential for generating a “wait anaphase” signal during mitosis, hereby ensuring accurate chromosome segregation. Inconsistent models for the function and quantitative contribution of the two mammalian Mad1 kinetochore receptors: Bub1 and the Rod‐Zw10‐Zwilch (RZZ) comp...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Zhang, Gang, Kruse, Thomas, Guasch Boldú, Claudia, Garvanska, Dimitriya H, Coscia, Fabian, Mann, Matthias, Barisic, Marin, Nilsson, Jakob
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443202/
https://ncbi.nlm.nih.gov/pubmed/30782962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100977
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