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Coupling of Cdc20 inhibition and activation by BubR1
Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by cyclin B1–Cdk1 independently inhi...
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| Publié dans: | J Cell Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Rockefeller University Press
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8025235/ https://ncbi.nlm.nih.gov/pubmed/33819340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202012081 |
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