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Coupling of Cdc20 inhibition and activation by BubR1

Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by cyclin B1–Cdk1 independently inhi...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Hein, Jamin B., Garvanska, Dimitriya H., Nasa, Isha, Kettenbach, Arminja N., Nilsson, Jakob
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025235/
https://ncbi.nlm.nih.gov/pubmed/33819340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202012081
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