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Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint
The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Checkpoint signalling requires the kinetochore localization of the Mad1–Mad2 complex that in more complex eukaryotes depends on the Rod–Zwilch–ZW10 (RZZ) com...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458899/ https://ncbi.nlm.nih.gov/pubmed/26031201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8162 |
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