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Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint
The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Checkpoint signalling requires the kinetochore localization of the Mad1–Mad2 complex that in more complex eukaryotes depends on the Rod–Zwilch–ZW10 (RZZ) com...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458899/ https://ncbi.nlm.nih.gov/pubmed/26031201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8162 |
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