Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition

BubR1 is essential for the mitotic checkpoint that prevents aneuploidy in cellular progeny by triggering anaphase delay in response to kinetochores incorrectly/not attached to the mitotic spindle. Here, we define the molecular architecture of the functionally significant N-terminal region of human B...

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Hauptverfasser: D'Arcy, Sheena, Davies, Owen R., Blundell, Tom L., Bolanos-Garcia, Victor M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863239/
https://ncbi.nlm.nih.gov/pubmed/20220147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082016
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