P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

Hemolytic diseases are frequently linked to multiorgan failure subsequent to vascular damage. Deciphering the mechanisms leading to organ injury upon hemolytic event could bring out therapeutic approaches. Complement system activation occurs in hemolytic disorders, such as sickle cell disease, but t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Merle, Nicolas S., Paule, Romain, Leon, Juliette, Daugan, Marie, Robe-Rybkine, Tania, Poillerat, Victoria, Torset, Carine, Frémeaux-Bacchi, Véronique, Dimitrov, Jordan D., Roumenina, Lubka T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442544/
https://ncbi.nlm.nih.gov/pubmed/30850533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814797116
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