P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

Hemolytic diseases are frequently linked to multiorgan failure subsequent to vascular damage. Deciphering the mechanisms leading to organ injury upon hemolytic event could bring out therapeutic approaches. Complement system activation occurs in hemolytic disorders, such as sickle cell disease, but t...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Merle, Nicolas S., Paule, Romain, Leon, Juliette, Daugan, Marie, Robe-Rybkine, Tania, Poillerat, Victoria, Torset, Carine, Frémeaux-Bacchi, Véronique, Dimitrov, Jordan D., Roumenina, Lubka T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442544/
https://ncbi.nlm.nih.gov/pubmed/30850533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814797116
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