Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Merle, Nicolas S., Leon, Juliette, Poillerat, Victoria, Grunenwald, Anne, Boudhabhay, Idris, Knockaert, Samantha, Robe-Rybkine, Tania, Torset, Carine, Pickering, Matthew C., Chauvet, Sophie, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426730/
https://ncbi.nlm.nih.gov/pubmed/32849636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01772
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