Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles

In hemolytic diseases, such as sickle cell disease (SCD), intravascular hemolysis results in the release of hemoglobin, heme, and heme-loaded membrane microvesicles in the bloodstream. Intravascular hemolysis is thus associated with inflammation and organ injury. Complement system can be activated b...

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Vydáno v:JCI Insight
Hlavní autoři: Merle, Nicolas S., Grunenwald, Anne, Rajaratnam, Helena, Gnemmi, Viviane, Frimat, Marie, Figueres, Marie-Lucile, Knockaert, Samantha, Bouzekri, Sanah, Charue, Dominique, Noe, Remi, Robe-Rybkine, Tania, Le-Hoang, Marie, Brinkman, Nathan, Gentinetta, Thomas, Edler, Monika, Petrillo, Sara, Tolosano, Emanuela, Miescher, Sylvia, Le Jeune, Sylvain, Houillier, Pascal, Chauvet, Sophie, Rabant, Marion, Dimitrov, Jordan D., Fremeaux-Bacchi, Veronique, Blanc-Brude, Olivier P., Roumenina, Lubka T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124427/
https://ncbi.nlm.nih.gov/pubmed/29925688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96910
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