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Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes
Aldo-Keto Reductase Family 7 Member A2 (AKR7A2) is the most abundant anthracycline metabolizing enzyme in human myocardium. Myocardial AKR7A2 contributes to the synthesis of cardiotoxic C-13 anthracycline alcohol metabolites (e.g., doxorubicinol). The factors that govern the transcription of human A...
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| Pubblicato in: | Toxicol Lett |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6441378/ https://ncbi.nlm.nih.gov/pubmed/30817976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2019.02.015 |
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