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Transcriptional Regulation of the Canine Carbonyl Reductase 1 Gene (cbr1) by the Specificity Protein 1 (Sp1)
The clinical use of anthracyclines to treat various canine cancers is limited by the development of cardiotoxicity. The intra-cardiac synthesis of anthracycline C-13 alcohol metabolites (e.g. daunorubicinol) contributes to the development of cardiotoxicity. Canine carbonyl reductase 1 (cbr1) catalyz...
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| Izdano u: | Gene |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5011011/ https://ncbi.nlm.nih.gov/pubmed/27506315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2016.08.005 |
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