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Role of DNA methylation on the expression of the anthracycline metabolizing enzyme AKR7A2 in human heart
The intracardiac synthesis of anthracycline alcohol metabolites by aldo-keto reductases (AKRs) contributes to the pathogenesis of anthracycline-related cardiotoxicity. AKR7A2 is the most abundant anthracycline reductase in hearts from donors with and without Down syndrome (DS), and its expression va...
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| Publicado no: | Cardiovasc Toxicol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643426/ https://ncbi.nlm.nih.gov/pubmed/25962911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-015-9327-x |
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