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Expression of the Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 in Hearts from Donors with Down Syndrome

Cancer patients with Down syndrome (DS) are susceptible to developing anthracycline-related cardiotoxicity. The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl reductase 1 (CBR1). CBR1 is located in the DS critical...

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Autors principals: Kalabus, James L., Sanborn, Carrie C., Jamil, Raqeeb G., Cheng, Qiuying, Blanco, Javier G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993452/
https://ncbi.nlm.nih.gov/pubmed/20729274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035550
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