The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation

Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been described. The KLF1 Nan variant, a single...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cantú, Ileana, van de Werken, Harmen J. G., Gillemans, Nynke, Stadhouders, Ralph, Heshusius, Steven, Maas, Alex, Esteghamat, Fatemehsadat, Ozgur, Zeliha, van IJcken, Wilfred F. J., Grosveld, Frank, von Lindern, Marieke, Philipsen, Sjaak, van Dijk, Thamar B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438607/
https://ncbi.nlm.nih.gov/pubmed/30921348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208659
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