Haploinsufficiency for the erythroid transcription factor KLF1 causes Hereditary Persistence of Fetal Hemoglobin

Hereditary Persistence of Fetal Hemoglobin (HPFH) is characterized by persistent high levels of fetal hemoglobin (HbF) in adults. Several contributory factors, both genetic and environmental, have been identified 1, but others remain elusive. Ten of twenty-seven members from a Maltese family present...

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Hlavní autoři: Borg, Joseph, Papadopoulos, Petros, Georgitsi, Marianthi, Gutiérrez, Laura, Grech, Godfrey, Fanis, Pavlos, Phylactides, Marios, Verkerk, Annemieke J.M.H., van der Spek, Peter J., Scerri, Christian A., Cassar, Wilhelmina, Galdies, Ruth, van IJcken, Wilfred, Özgür, Zeliha, Gillemans, Nynke, Hou, Jun, Bugeja, Marisa, Grosveld, Frank G., von Lindern, Marieke, Felice, Alex E., Patrinos, George P., Philipsen, Sjaak
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930131/
https://ncbi.nlm.nih.gov/pubmed/20676099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.630
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