The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation

Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been described. The KLF1 Nan variant, a single...

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Udgivet i:PLoS One
Main Authors: Cantú, Ileana, van de Werken, Harmen J. G., Gillemans, Nynke, Stadhouders, Ralph, Heshusius, Steven, Maas, Alex, Esteghamat, Fatemehsadat, Ozgur, Zeliha, van IJcken, Wilfred F. J., Grosveld, Frank, von Lindern, Marieke, Philipsen, Sjaak, van Dijk, Thamar B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438607/
https://ncbi.nlm.nih.gov/pubmed/30921348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208659
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