The Novel β-Lactam Enhancer Zidebactam Augments the In Vivo Pharmacodynamic Activity of Cefepime in a Neutropenic Mouse Lung Acinetobacter baumannii Infection Model

WCK 5222 is a combination of cefepime and the high-affinity PBP2-binding β-lactam enhancer zidebactam. The cefepime-zidebactam combination is active against multidrug-resistant Gram-negative bacteria, including carbapenemase-expressing Acinetobacter baumannii. The mechanism of action of the combinat...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Bhagwat, S. S., Periasamy, H., Takalkar, S. S., Palwe, S. R., Khande, H. N., Patel, M. V.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437547/
https://ncbi.nlm.nih.gov/pubmed/30670419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02146-18
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