In Vitro and In Vivo Activities of β-Lactams in Combination with the Novel β-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-β-Lactamase-Producing Klebsiella pneumoniae

Zidebactam and WCK 5153 are novel bicyclo-acyl hydrazide (BCH) agents that have previously been shown to act as β-lactam enhancer (BLE) antibiotics in Pseudomonas aeruginosa and Acinetobacter baumannii. The objectives of this work were to identify the molecular targets of these BCHs in Klebsiella pn...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Moya, Bartolome, Barcelo, Isabel M., Cabot, Gabriel, Torrens, Gabriel, Palwe, Snehal, Joshi, Prashant, Umarkar, Kushal, Takalkar, Swapna, Periasamy, Hariharan, Bhagwat, Sachin, Patel, Mahesh, Bou, German, Oliver, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496095/
https://ncbi.nlm.nih.gov/pubmed/30782985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00128-19
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