Potent β-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates

Multidrug-resistant Acinetobacter baumannii has rapidly spread worldwide, resulting in a serious threat to hospitalized patients. Zidebactam and WCK 5153 are novel non-β-lactam bicyclo-acyl hydrazide β-lactam enhancer antibiotics being developed to target multidrug-resistant A. baumannii. The object...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Moya, Bartolome, Barcelo, Isabel M., Bhagwat, Sachin, Patel, Mahesh, Bou, German, Papp-Wallace, Krisztina M., Bonomo, Robert A., Oliver, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655067/
https://ncbi.nlm.nih.gov/pubmed/28848013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01238-17
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