In Vivo Efficacy of Humanized WCK 5222 (Cefepime-Zidebactam) Exposures against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Thigh Model

Herein, we describe the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against carbapenem-resistant Acinetobacter baumannii strains in a neutropenic murine thigh infection model. Five of the six isolates examined expressed OXA-23 or OXA-24. WCK 5222, despite showing MICs...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Almarzoky Abuhussain, Safa S., Avery, Lindsay M., Abdelraouf, Kamilia, Nicolau, David P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325183/
https://ncbi.nlm.nih.gov/pubmed/30373797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01931-18
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