In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model

We describe the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against multidrug-resistant Pseudomonas aeruginosa (meropenem MICs 8 to >256 μg/ml) in a neutropenic murine thigh infection model. WCK 5222 MICs ranged from 4 to 32 μg/ml. Substantial in vivo WCK 5222 acti...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Monogue, Marguerite L., Tabor-Rennie, Jennifer, Abdelraouf, Kamilia, Nicolau, David P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591597/
https://ncbi.nlm.nih.gov/pubmed/31235557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00233-19
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