In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist

Recently, our group along with another demonstrated that GPR139 can be activated by L-phenylalanine (L-Phe) and L-tryptophan (L-Trp) at physiologically relevant concentrations. GPR139 is discretely expressed in brain, with highest expression in medial habenula. Not only are the endogenous ligands ca...

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Publicat a:Front Pharmacol
Autors principals: Shoblock, James R., Welty, Natalie, Fraser, Ian, Wyatt, Ryan, Lord, Brian, Lovenberg, Timothy, Liu, Changlu, Bonaventure, Pascal
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437111/
https://ncbi.nlm.nih.gov/pubmed/30949055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00273
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