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Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro

It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via G(αq)-coupling. The in vitro affinity and potency values of L-Trp and L-Phe are within...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Nepomuceno, Diane, Kuei, Chester, Dvorak, Curt, Lovenberg, Timothy, Liu, Changlu, Bonaventure, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863515/
https://ncbi.nlm.nih.gov/pubmed/29599718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00157
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