Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and high throug...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Wang, Lien, Lee, Grace, Shih, Amy, Kuei, Chester, Nepomuceno, Diane, Wennerholm, Michelle, Fan, Frances, Wu, Jiejun, Bonaventure, Pascal, Lovenberg, Timothy W., Liu, Changlu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367278/
https://ncbi.nlm.nih.gov/pubmed/30774960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.466
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