Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and high throug...

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Bibliografiska uppgifter
I publikationen:Pharmacol Res Perspect
Huvudupphovsmän: Wang, Lien, Lee, Grace, Shih, Amy, Kuei, Chester, Nepomuceno, Diane, Wennerholm, Michelle, Fan, Frances, Wu, Jiejun, Bonaventure, Pascal, Lovenberg, Timothy W., Liu, Changlu
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367278/
https://ncbi.nlm.nih.gov/pubmed/30774960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.466
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