Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and high throug...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmacol Res Perspect
Prif Awduron: Wang, Lien, Lee, Grace, Shih, Amy, Kuei, Chester, Nepomuceno, Diane, Wennerholm, Michelle, Fan, Frances, Wu, Jiejun, Bonaventure, Pascal, Lovenberg, Timothy W., Liu, Changlu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367278/
https://ncbi.nlm.nih.gov/pubmed/30774960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.466
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