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Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA-mediated Ca(2+)-influx, LTP impairment and neurotoxicity
Amyloid protein misfolding results in a self-assembling aggregation process, characterized by the formation of typical aggregates. The attention is focused on pre-fibrillar oligomers (PFOs), formed in the early stages and supposed to be neurotoxic. PFOs structure may change due to their instability...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6435710/ https://ncbi.nlm.nih.gov/pubmed/30914688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41462-0 |
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