Role of Electrostatic Interactions in Calcitonin Prefibrillar Oligomer-Induced Amyloid Neurotoxicity and Protective Effect of Neuraminidase

Salmon calcitonin is a good model for studying amyloid behavior and neurotoxicity. Its slow aggregation rate allows the purification of low molecular weight prefibrillar oligomers, which are the most toxic species. It has been proposed that these species may cause amyloid pore formation in neuronal...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Cariati, Ida, Bonanni, Roberto, Marini, Mario, Rinaldi, Anna Maria, Zarrilli, Beatrice, Tancredi, Virginia, Frank, Claudio, D’Arcangelo, Giovanna, Diociaiuti, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070249/
https://ncbi.nlm.nih.gov/pubmed/33920464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22083947
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