Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA-mediated Ca(2+)-influx, LTP impairment and neurotoxicity

Amyloid protein misfolding results in a self-assembling aggregation process, characterized by the formation of typical aggregates. The attention is focused on pre-fibrillar oligomers (PFOs), formed in the early stages and supposed to be neurotoxic. PFOs structure may change due to their instability...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Belfiore, Marcello, Cariati, Ida, Matteucci, Andrea, Gaddini, Lucia, Macchia, Gianfranco, Fioravanti, Raoul, Frank, Claudio, Tancredi, Virginia, D’Arcangelo, Giovanna, Diociaiuti, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435710/
https://ncbi.nlm.nih.gov/pubmed/30914688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41462-0
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