Top-Down Characterization of Proteins with Intact Disulfide Bonds Using Activated-Ion Electron Transfer Dissociation

Here we report the fragmentation of disulfide linked intact proteins using activated-ion electron transfer dissociation (AI-ETD) for top-down protein characterization. This fragmentation method is then compared to the alternative methods of HCD, ETD, and EThcD. We analyzed multiple precursor charge...

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Bibliographic Details
Published in:Anal Chem
Main Authors: Rush, Matthew J.P., Riley, Nicholas M., Westphall, Michael S., Coon, Joshua J.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434944/
https://ncbi.nlm.nih.gov/pubmed/29949341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b01113
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