Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1

Human indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO) catalyze the same dioxygenation reaction of Trp to generate N-formyl kynurenine (NFK). They share high structural similarity, especially in the active site. However, hIDO1 possesses a unique inhibitory substrate binding si...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Lewis-Ballester, Ariel, Karkashon, Shay, Batabyal, Dipanwita, Poulos, Thomas L., Yeh, Syun-Ru
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434940/
https://ncbi.nlm.nih.gov/pubmed/29897749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b03691
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