Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor genetically linked to the risk for Alzheimer’s disease (AD). A proteolytic product, soluble TREM2 (sTREM2), is abundant in the cerebrospinal fluid and its levels positively correlate with neuronal injury marker...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Zhong, Li, Xu, Ying, Zhuo, Rengong, Wang, Tingting, Wang, Kai, Huang, Ruizhi, Wang, Daxin, Gao, Yue, Zhu, Yifei, Sheng, Xuan, Chen, Kai, Wang, Na, Zhu, Lin, Can, Dan, Marten, Yuka, Shinohara, Mitsuru, Liu, Chia-Chen, Du, Dan, Sun, Hao, Wen, Lei, Xu, Huaxi, Bu, Guojun, Chen, Xiao-Fen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433910/
https://ncbi.nlm.nih.gov/pubmed/30911003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09118-9
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