A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function

The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy. In the kidney, the enzyme DOPA Decarboxylase (DDC) originating from the circulation. We used a twin/family study design...

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Publicado en:Sci Rep
Autores principales: Miramontes-Gonzalez, Jose Pablo, Hightower, Makena, Zhang, Kuixing, Kurosaki, Hiroki, Schork, Andrew J., Biswas, Nilima, Vaingankar, Sucheta, Mahata, Manjula, Lipkowitz, Michael S., Nievergelt, Caroline M., Baker, Dewleen G., Ziegler, Michael G., León-Jiménez, David, González-Sarmiento, Rogelio, Ichinose, Hiroshi, O’Connor, Daniel T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433864/
https://ncbi.nlm.nih.gov/pubmed/30911067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41504-7
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