Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

BACKGROUND: Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin...

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Detalhes bibliográficos
Publicado no:BMC Med Genet
Main Authors: Biswas, Nilima, Maihofer, Adam X., Mir, Saiful Anam, Rao, Fangwen, Zhang, Kuixing, Khandrika, Srikrishna, Mahata, Manjula, Friese, Ryan S., Hightower, C. Makena, Mahata, Sushil K., Baker, Dewleen G., Nievergelt, Caroline M., Vaingankar, Sucheta M., O’Connor, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788869/
https://ncbi.nlm.nih.gov/pubmed/26969407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-016-0283-5
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