Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

BACKGROUND: Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin...

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Detaylı Bibliyografya
Yayımlandı:BMC Med Genet
Asıl Yazarlar: Biswas, Nilima, Maihofer, Adam X., Mir, Saiful Anam, Rao, Fangwen, Zhang, Kuixing, Khandrika, Srikrishna, Mahata, Manjula, Friese, Ryan S., Hightower, C. Makena, Mahata, Sushil K., Baker, Dewleen G., Nievergelt, Caroline M., Vaingankar, Sucheta M., O’Connor, Daniel T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788869/
https://ncbi.nlm.nih.gov/pubmed/26969407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-016-0283-5
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