Chromogranin B (CHGB): Intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

CHGB is the major matrix protein in human catecholamine storage vesicles. CHGB genetic variation alters catecholamine secretion and blood pressure. Here effective Chgb protein under-expression was achieved by siRNA in PC12 cells, resulting in ~48% fewer secretory granules on EM, diminished capacity...

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Bibliografiske detaljer
Main Authors: Zhang, Kuixing, Biswas, Nilima, Gayen, Jiaur R., Miramontes-Gonzalez, Jose Pablo, Hightower, C. Makena, Mustapic, Maja, Mahata, Manjula, Huang, Chun-Teng, Hook, Vivian Y., Mahata, Sushil K., Vaingankar, Sucheta, O'Connor, Daniel T.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992281/
https://ncbi.nlm.nih.gov/pubmed/24266713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12527
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