Chromogranin B (CHGB): Intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

CHGB is the major matrix protein in human catecholamine storage vesicles. CHGB genetic variation alters catecholamine secretion and blood pressure. Here effective Chgb protein under-expression was achieved by siRNA in PC12 cells, resulting in ~48% fewer secretory granules on EM, diminished capacity...

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Hauptverfasser: Zhang, Kuixing, Biswas, Nilima, Gayen, Jiaur R., Miramontes-Gonzalez, Jose Pablo, Hightower, C. Makena, Mustapic, Maja, Mahata, Manjula, Huang, Chun-Teng, Hook, Vivian Y., Mahata, Sushil K., Vaingankar, Sucheta, O'Connor, Daniel T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992281/
https://ncbi.nlm.nih.gov/pubmed/24266713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12527
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