Effects of chromogranin A Deficiency and Excess in vivo: Biphasic Blood Pressure and Catecholamine Responses

OBJECTIVE: The phenotype of the Chromogranin A(Chga) null (knockout) mouse is hypertensive. However, hypertensive humans and spontaneously hypertensive rats display elevated CHGA expression. This study addresses the paradox that both ablation and elevation of CHGA result in hypertension. METHODS: Mi...

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Main Authors: Vaingankar, Sucheta M., Li, Ying, Biswas, Nilima, Gayen, Jiaur, Choksi, Sonia, Rao, Fangwen, Ziegler, Michael G., Mahata, Sushil K., O'Connor, Daniel T.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947860/
https://ncbi.nlm.nih.gov/pubmed/20139771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e328336ed3e
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