Probe dependence of allosteric enhancers on the binding affinity of adenosine A(1)‐receptor agonists at rat and human A(1)‐receptors measured using NanoBRET

BACKGROUND AND PURPOSE: Adenosine is a local mediator that regulates a number of physiological and pathological processes via activation of adenosine A(1)‐receptors. The activity of adenosine can be regulated at the level of its target receptor via drugs that bind to an allosteric site on the A(1)‐r...

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Udgivet i:Br J Pharmacol
Main Authors: Cooper, Samantha L., Soave, Mark, Jörg, Manuela, Scammells, Peter J., Woolard, Jeanette, Hill, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433648/
https://ncbi.nlm.nih.gov/pubmed/30644086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14575
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