Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase

Astrotactin 1 (Astn1) and Astn2 are membrane proteins that function in glial-guided migration, receptor trafficking, and synaptic plasticity in the brain as well as in planar polarity pathways in the skin. Here we used glycosylation mapping and protease protection approaches to map the topologies of...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Lara, Patricia, Tellgren-Roth, Åsa, Behesti, Hourinaz, Horn, Zachi, Schiller, Nina, Enquist, Karl, Cammenberg, Malin, Liljenström, Amanda, Hatten, Mary E., von Heijne, Gunnar, Nilsson, IngMarie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433051/
https://ncbi.nlm.nih.gov/pubmed/30696770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007093
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