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Contribution of positively charged flanking residues to the insertion of transmembrane helices into the endoplasmic reticulum

Positively charged residues located near the cytoplasmic end of hydrophobic segments in membrane proteins promote membrane insertion and formation of transmembrane α-helices. A quantitative understanding of this effect has been lacking, however. Here, using an in vitro transcription–translation syst...

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Detalhes bibliográficos
Main Authors: Lerch-Bader, Mirjam, Lundin, Carolina, Kim, Hyun, Nilsson, IngMarie, von Heijne, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2393759/
https://ncbi.nlm.nih.gov/pubmed/18326626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711580105
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