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Orientational preferences of neighboring helices can drive ER insertion of a marginally hydrophobic transmembrane helix

α-helical integral membrane proteins critically depend on the correct insertion of their transmembrane α-helices into the lipid bilayer for proper folding, yet a surprisingly large fraction of the transmembrane α-helices in multispanning integral membrane proteins are not sufficiently hydrophobic to...

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Autors principals: Öjemalm, Karin, Halling, Katrin K., Nilsson, IngMarie, von Heijne, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553544/
https://ncbi.nlm.nih.gov/pubmed/22281052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.12.024
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